Medicinal Chemistry 2015

Centre for Analysis and Synthesis, Lund University

Medicinal Chemistry KOKN01 for students at LTH and  KEMM20 for students at the Faculty of Sciences, 7.5 hp.
30 h lectures.

Course WIKI

General information

The course aims at providing basic knowledge in and broad understanding of medicinal chemistry and pharmacological principles from a molecular perspective. You will study the most common approaches towards drug development, target identification, common targets for drugs, and pharmacodynamics and pharmacokinetics. Important therapeutic ares will be exemplified and discussed. You will learn how to discuss properties of drug molecules, value a given structure as a potential lead compound or drug candidate, and improve drug-like properties of a given structure. The course is based on lectures complemented with exercises and discussions.
Course leader
Professor Ulf Nilsson (see home page here)
Examination
Written exam.
1. If you have questions please do not email to me, but instead post your question or problem solution suggestion on the wiki or blog.

2. You can use molecular model building sets on the exam. You can bring your own and I will bring some that will be available.

3. You can bring a dictionary to the written exam, but it has to be left with the exam personnel.

4. I will bring a periodic table to the written exam for those who wish to have it. You can not bring your own.

5. I will bring to the written exam the chapter summaries for you.
Literature - sold on campus at KFS Studentliterature
Patrick
Graham L. Patrick, An introduction to Medicinal Chemistry.
Oxford University Press, 5th edition, 2013. ISBN 978-0-19-969739-7.

Lecture and exercise scheme 2015



Day Time Hall Subject Lecturer

We 2/9 1000 K:F Call for KEMM20
Christina Persson

We 2/9 1015-12 K:F Call for KOKN01
Introduction (1) 
UN

Th 3/9 8-10 K:F Proteins (2) UN

Fr 4/9
10-12 K:F Enzymes (3 and 7) UN

Tu 8/9 10-12 K:M Exercise 1
UN, AD

We 9/9 10-12 K:F Receptors, structure, function, and drug targets (4 and 8) UN

Th 10/9 8-10 K:F Receptors and signal transduction (5) UN

Fr 11/9
10-12 K:F Pharmacokinetics (11) UN

Tu 15/9 10-12 K:F
Drug discovery: finding a lead (12) UN

We 16/9 10-12 K:F
Drug design: optimizing target interactions (13) UN

Th 17/9 8-10 K:F Drug design: optimizing access to the target (14) UN

Fr 18/9
10-12 K:F Drug development (15) UN

Tu 22/9 10-12 K:F Antiviral agents (20) UN

We 23/9 10-12 K:M Exercise 2 UN, AD

Th 24/9 8-10 K:F Antibiotics (19) Johan Wennerberg,
DuPont Chemoswed

Fr 25/9
10-12 K:M Exercise 3 UN, AD

Tu 29/9 10-12 K:F Nucleic acids (6-9)  No lecture - self studies

We 30/9 10-12 K:F Cholinergics, anticholinergics and anticholinesterases (22)
The adrenergic nervous system (23)
UN

Th 1/10 8-10 K:F Anti-cancer agents (21) Johan Wennerberg,
DuPont Chemoswed

Fr 2/10
10-12 K:M Exercise 4 UN, AD

Tu 6/10 10-12 K:F Computers in medicinal chemistry (17-18)
Björn Walse och Bo Svensson
SARomics Biostructures AB

We 7/10 10-12 K:F The adrenergic nervous system (23)
The opium analgesics (24)
UN

Th 8/10 8-10 K:F Antiulcer agents (25) UN

Fr 9/10
10-12 K:F Exercise 5 UN, AD

Tu 13/10 10-12 K:G Biopharmaceuticals UN

We 45/10 10-12 K:F AZ case and Biotech case Fredrik Zetterberg and UN

Th 15/10 8-10 K:F
Anti-coagulantia Johan Wennerberg

Fr 16/10
10-12 K:G Exercise 6 UN

Tue 27/10 17:00!!!

Deadline for writing summary chapters!




K:
Extra exercise - question hours
UN, AD

Thu 29/10 8-13 Eden 025
Exam

Problems at the exercises. A recommendation.

Underlined bold face exercises are suggested for solution presentations on the white board

Exercise 1:
1.1, 1.2, 1.8, 3.2, 3.4, 4.3, 4.4, 5.1, 5.5, 5.6, 7.2, 7.3, 7.4, 8.1, 8.2, 8.5, 8.6, 8.7

Exercise 2:

11.1-2, 11.3-4, 11.6-7, 12.1, 12.2, 12.3, 12.5-6, 13.1-2, 13.6-8, 13.9-10, 13.12, 13.13, 13.15

Exercise 3:
14.3-4, 14.5, 14.6-7, 14.9, 14.10, 15.2, 16.1, 16.4, 19.8

Exercise 4:
20.3, 20.4-5, 20.8, 21.1-2, 21.4-5, 21.6-7, 21.8-9, exam 101018-problem 8-9

Exercise 5:
17.1-2, 17.4, 17.5-6, 17.7, 17.9, 22.1, 22.5, 22.6, 22.7-8, 22.9, 23.3-5,  091021-problem 1-2, 081021-problem 7, 071017-problem 3, 11.

Exercise 6:
24.10-11, 24.15, 25.1, 25.4, (Old exam if time permits)

The quiz question collection is on the wiki

Examination

The exam will consist of two parts. Part A will be conceptual question requiring only short (fact) answers. Part B will be problem solving questions where you need to demonstrate analytical and creative skills  as well. You need at least half of the points from part A to pass the exam and you also need at at least half of the total points to pass the exam.
Typical examples of part A questions would be like problems 1,2, and 6 in the exam 101018. Typical examples of part B questions would be like problems 3 8, and 9 in the same exam.

The written exam will take place on October 29 at 8-13 in Eden 025

Extra examination 2016 on January 4 at 8-13 in K:H-I and in May (to be announced)

Register for extra exams here!
You have to register at least one week in advance
name:
email:
date:
 

Lecturer from organic chemistry

Secretary: Maria Levin, tel 046-222 8210, fax 046 222 8209