About galectins

The galectins are a family of intra- and extracellular galactoside-binding lectins that binds and at least sometimes cross-links glycoconjugates. By doing so, they play important roles in immune regulation, which in turn manifests itself in rate-limiting roles in immunological conditions and cancer. Lund University hosts a network of several collaborating research groups with leading activities ranging theoretical studies of galectin proteins and their ligands to in vivo investigations of galectin functions and involvement in disease mechanisms.

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Research groups

Theoretical studies of galectin-ligand complexes are done in the research group of theoretical chemistry professor Ulf Ryde.

Crystallographic studies of galectin-3 and its complexes are performed by biostructural chemistry associate professor Derek Logan.

NMR structural and dynamical investigations are done by biophysical chemistry professor Mikael Akke.

Organic and medicinal chemistry of galectin ligands and inhibitors are done by organic chemistry professor Ulf J. Nilsson.

Biomolecular mechanisms of galectins are studied the research group of molecular medicine professor Hakon Leffler.

Cell biology professor Stina Oredsson investigates the roles of galectins and their inhibition effects on tumor cells.

Tomas Deierborg, associate professor in neuroscience, investigates the role of galectin 3 in microglia and its function in stroke and neurodegenerative diseases.

Companies

Galecto Biotech AB is a new Lund-based company developing galectin antagonist as novel drugs.

SARomics Biostructures AB is a drug discovery and structural biology CRO that has determined ultra-high resolution galectin-3 structures.