127 peer-reviewed original research publications

Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands
K. Peterson, P. M. Collins, X. Huang, B. Kahl-Knutsson, F. R. Zetterberg, S. Oredsson, H. Leffler, H. Blanchard, and U. J. Nilsson
RSC Advances, 2018, 8, 24913-24922.

J. Nilsson, A. Blomgren, U. J. Nilsson, E. D. Högestätt, L. Grundemar
N,N'-Bis(2-mercaptoethyl)isophthalamide binds electrophilic paracetamol metabolites and prevents paracetamol-induced liver toxicity
Basic Clin. Pharmacol. Toxicol., accepted , 2018

W. Yuan Wahlgren, R. North, E. Dunevall, A. Paz, M. Scalise, P. Bisignano, P. Goyal, E. Claesson, J. Bengtsson-Palme, R. C. Carlsson, R. Andersson, G. Askarieh, K. Beis, U. J. Nilsson, A. Farewell, L. Pochini, C. Indiveri, M. Grabe, R. C. J. Dobson, J. Abramson, S. Ramaswamy, and R. Friemann
Substrate-bound outward-open state of Na+-coupled sialic acid symporter reveals Na3 site
Nat. commun., 2018, 9, 1753

K. B. Pal, M. Mahanti, U. J. Nilsson
Arynes in Transition-Metal-Free Monoarylation of Unprotected Carbohydrate amines
Org. Lett., 2018, 20, 616-619

Y. Uchino, A. Woodward, J. Mauris, K. Peterson, P. Verma, U. J. Nilsson, J. Rajaiya, P. Argueso
Galectin-3 is an amplifier of the interleukin-1β-mediated inflammatory response in corneal keratinocyte
Immunology, 2018, 154, 490–499

K. Peterson, R. Kumar, O. Stenström, P. Vermaa, P. R. Verma, M. Håkansson, B. Kahl-Knutsson, F. Zetterberg, H. Leffler, M. Akke, D. T. Logan, U. J. Nilsson
Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity
J. Med. Chem., 2018, 61, 1164-1175, DOI: 10.1021/acs.jmedchem.7b01626

A.-L. Noresson, O. Aurelius, C. T. Öberg, O. Engström, A. Sundin, M. Håkansson, O. Stenström, M. Akke, D. Logan, H. Leffler, and U. J. Nilsson
Designing interactions by control of protein-ligand complex conformation: Tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions
Chem. Sci., 2018, 9, 1014, DOI: 10.1039/c7sc04749e

F. R. Zetterberg, K. Peterson, R. Johnsson, T. Brimert, M. Håkansson, H Leffler, and U. J. Nilsson
Monosaccharide derivatives with low nM lectin affinity and high selectivity based on combined fluorine-amide, phenyl-arginine, sulfur-π, and halogen bond interactions
ChemMedChem, 2018, 13, 133-137. DOI: 10.1002/cmdc.201700744

I. Fritzson, B. Svensson, U. Wellmar, U. J. Nilsson, D. da Graca Thrige, S. Jönsson
Human DHODH Inhibition and Structure-Activity Relationships for 4-Hydroxycoumarines, Fenamic Acids and N-(Alkylcarbonyl)-anthranilic Acids Identified by SBDD-Guided Fragment Screening
, 2010, 5, 608-617.

C.-I. Lin, E. E. Whang, M. A. Abramson, X. Jiang, B. D. Price, D. B. Donner, A. M. Carothers, T. Delaine, H. Leffler, U. J. Nilsson, F. D. Jr. Moore, D. T. Ruan Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and improves both chemosensitivity and radiosensitivity in papillary thyroid cancers
Mol. Cancer Res. 2009, 7, 1655-1662.