134 peer-reviewed original research publications
5 invited reviews
7 invited chapters in edited books
1 course book
20 patent families comprising of a total of 32 patents and 42 pending applications
161 conference contributions


M. L. Verteramo, O. Stenström, M. M. Ignjatovic, O. Caldararu, M. Olsson, F. Manzoni, H. Leffler, E. Oksanen, D. Logan, U. J. Nilsson, U. Ryde, and M. Akke
Interplay between Conformational Entropy and Solvation Entropy in Protein–Ligand Binding
J. Am. Chem. Soc., 2018, 141, 2012-2026


R. Kumar, K. Peterson, M. M. Ignjatovic, H. Leffler, U. Ryde, U. J. Nilsson, and D. T. Logan
Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects
Org. Biomol. Chem., 2019, 17, 1081-1089


Intracellular activity of small molecule galectin-3 inhibitors with high or low cell membrane permeability
J. Stegmayr, M. C. Carlsson, G. Sharma, X. Huang, F. Zetterberg, B. Kahl-Knutson, H. Schambye, U. J. Nilsson, S. Oredsson, H. Leffler
Sci. Rep., accepted, 2019


Ž. Bojić-Trbojević, M. Jovanović Krivokuća, A. Vilotić, N. Kolundžić, I. Stefanoska, F. Zetterberg, U. J. Nilsson, H. Leffler, L. Vićovac
Human trophoblast requires galectin-3 for cell migration and invasion
Sci. Rep., 2019, 9:2136


L. Vuong, E. Kouverianou, C. Rooney, B. J. McHugh, S. E. Howie, C. Gregory, S. J. Forbes, N. C. Henderson, F.  R. Zetterberg, U. J. Nilsson, H. Leffler, P. Ford, A. Pedersen, L. Gravelle, S. Tantawi, H. Schambye, M. Whyte, T. Sethi, and A. C. MacKinnon
Novel High Affinity Small Molecule Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Metastasis
Cancer Res., accepted, 2019


M. Ingemann Nielsen, J. Stegmayr, U. J. Nilsson, I. Boos, M. C. Carlsson, C. Unverzagt, H. Leffler, H. H. Wandall
Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context
J. Biol. Chem., 2018, 293, 20249 –20262, DOI10.1074/jbc.RA118.004636


K. B. Pal, M. Mahanti, X. Huang, S. Persson, A. P. Sundin, F. R. Zetterberg, S. Oredsson, H. Leffler, and U. J. Nilsson
Quinoline-galactose hybrids bind selectively with high affinity to galectin-8 N-terminal domain
Org. Biomol. Chem., 2018, 16, 6295-6305; DOI: 10.1039/C8OB01354C


Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands
K. Peterson, P. M. Collins, X. Huang, B. Kahl-Knutsson, F. R. Zetterberg, S. Oredsson, H. Leffler, H. Blanchard, and U. J. Nilsson
RSC Advances, 2018, 8, 24913-24922.


J. Nilsson, A. Blomgren, U. J. Nilsson, E. D. Högestätt, L. Grundemar
N,N'-Bis(2-mercaptoethyl)isophthalamide binds electrophilic paracetamol metabolites and prevents paracetamol-induced liver toxicity
Basic Clin. Pharmacol. Toxicol., 2018, 123, 589–593, Doi: 10.1111/bcpt.13058


W. Yuan Wahlgren, R. North, E. Dunevall, A. Paz, M. Scalise, P. Bisignano, P. Goyal, E. Claesson, J. Bengtsson-Palme, R. C. Carlsson, R. Andersson, G. Askarieh, K. Beis, U. J. Nilsson, A. Farewell, L. Pochini, C. Indiveri, M. Grabe, R. C. J. Dobson, J. Abramson, S. Ramaswamy, and R. Friemann
Substrate-bound outward-open state of Na+-coupled sialic acid symporter reveals Na3 site
Nat. commun., 2018, 9, 1753


K. B. Pal, M. Mahanti, U. J. Nilsson
Arynes in Transition-Metal-Free Monoarylation of Unprotected Carbohydrate amines
Org. Lett., 2018, 20, 616-619


Y. Uchino, A. Woodward, J. Mauris, K. Peterson, P. Verma, U. J. Nilsson, J. Rajaiya, P. Argueso
Galectin-3 is an amplifier of the interleukin-1β-mediated inflammatory response in corneal keratinocyte
Immunology, 2018, 154, 490–499

K. Peterson, R. Kumar, O. Stenström, P. Vermaa, P. R. Verma, M. Håkansson, B. Kahl-Knutsson, F. Zetterberg, H. Leffler, M. Akke, D. T. Logan, U. J. Nilsson
Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity
J. Med. Chem., 2018, 61, 1164-1175, DOI: 10.1021/acs.jmedchem.7b01626


A.-L. Noresson, O. Aurelius, C. T. Öberg, O. Engström, A. Sundin, M. Håkansson, O. Stenström, M. Akke, D. Logan, H. Leffler, and U. J. Nilsson
Designing interactions by control of protein-ligand complex conformation: Tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions
Chem. Sci., 2018, 9, 1014, DOI: 10.1039/c7sc04749e


F. R. Zetterberg, K. Peterson, R. Johnsson, T. Brimert, M. Håkansson, H Leffler, and U. J. Nilsson
Monosaccharide derivatives with low nM lectin affinity and high selectivity based on combined fluorine-amide, phenyl-arginine, sulfur-π, and halogen bond interactions
ChemMedChem, 2018, 13, 133-137. DOI: 10.1002/cmdc.201700744


I. Fritzson, B. Svensson, U. Wellmar, U. J. Nilsson, D. da Graca Thrige, S. Jönsson
Human DHODH Inhibition and Structure-Activity Relationships for 4-Hydroxycoumarines, Fenamic Acids and N-(Alkylcarbonyl)-anthranilic Acids Identified by SBDD-Guided Fragment Screening
ChemMedChem
, 2010, 5, 608-617.

C.-I. Lin, E. E. Whang, M. A. Abramson, X. Jiang, B. D. Price, D. B. Donner, A. M. Carothers, T. Delaine, H. Leffler, U. J. Nilsson, F. D. Jr. Moore, D. T. Ruan Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and improves both chemosensitivity and radiosensitivity in papillary thyroid cancers
Mol. Cancer Res. 2009, 7, 1655-1662.